Circulating MicroRNAs predict glycemic improvement and response to a behavioral intervention

Biomarker Research

Table 2 Standardized^a MicroRNA Predictors of Fasting Blood Glucose

	Fasting Blood Glucoseat 12-Months			Change in Fasting Blood Glucose after 12-Months
R²(p-value)	0.754 (p < 0.001)			0.731 (p < 0.001)
	β	SE	p-value	β	SE	p-value
(Constant)	116.835	9.455	< 0.001
let-7c-5p	57.793	17.213	0.006	36.473	15.538	0.039
miR-17-5p	103.369	56.573	0.095	115.762	51.070	0.045
miR-20b-5p	-44.197	19.784	0.047	-46.590	17.859	0.024
miR-22-3p	54.453	21.730	0.029	40.900	19.616	0.061
miR-92a-3p	153.475	75.753	0.068	155.501	68.383	0.044
miR-93-5p	109.430	47.467	0.042	102.078	42.849	0.036
miR-106b-5p	-36.680	12.263	0.012	-26.795	11.070	0.034
mir-186-5p	-10.961	22.123	0.283	-12.247	23.123	0.456
miR-192-5p	-57.402	21.394	0.021	-41.995	19.312	0.052
miR-197-3p	82.176	32.636	0.029
miR-296-5p	42.881	13.913	0.010	35.448	12.560	0.017
miR-342-3p	29.558	11.615	0.027	25.671	10.485	0.032
miR-363-3p	24.191	11.045	0.051
miR-374b-5p	40.072	22.111	0.097	36.522	19.960	0.094

^aBecause expression levels measured by flow cytometry cannot be directly compared between individual microRNAs, all microRNA values were standardized to z-scores so that the mean expression level is equal to zero and a 1-unit change is equal to one standard deviation from the mean
β beta value; SE standard error

ISSN: 2050-7771